Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.03 | 1 | |
Onchocerca volvulus | 0.0058 | 0.03 | 1 | |
Onchocerca volvulus | 0.0058 | 0.03 | 1 | |
Brugia malayi | Reduced folate carrier family protein | 0.0058 | 0.03 | 0.5 |
Onchocerca volvulus | 0.0038 | 0.0083 | 0.276 | |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0058 | 0.03 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0172 | 0.1521 | 1 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0172 | 0.1521 | 1 |
Giardia lamblia | Hypothetical protein | 0.0058 | 0.03 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0237 | 0.2214 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0038 | 0.0083 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.03 | 1 | |
Echinococcus multilocularis | folate receptor beta | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Brugia malayi | folate-like transporter 3 | 0.0058 | 0.03 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1527 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0058 | 0.03 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0172 | 0.1521 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0058 | 0.03 | 1 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0058 | 0.03 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.03 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.