Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | prolyl endopeptidase | 0.0733 | 0.8915 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0309 | 0.1864 | 0.2091 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0309 | 0.1864 | 0.2091 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0733 | 0.8915 | 0.8915 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0309 | 0.1864 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0733 | 0.8915 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0309 | 0.1864 | 0.2091 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0309 | 0.1864 | 0.5 |
Leishmania major | oligopeptidase b | 0.0309 | 0.1864 | 0.2091 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0798 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.013 | 0.013 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0798 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0733 | 0.8915 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0733 | 0.8915 | 0.8915 |
Toxoplasma gondii | prolyl endopeptidase | 0.0733 | 0.8915 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.044 | 0.4039 | 0.4039 |
Trypanosoma cruzi | oligopeptidase b | 0.0309 | 0.1864 | 0.2091 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0733 | 0.8915 | 0.8915 |
Brugia malayi | prolyl oligopeptidase family protein | 0.044 | 0.4039 | 0.453 |
Trypanosoma brucei | prolyl endopeptidase | 0.0733 | 0.8915 | 1 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.0309 | 0.1864 | 0.2091 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.063 | 0.7205 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.013 | 0.013 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.044 | 0.4039 | 0.4039 |
Echinococcus granulosus | prolyl endopeptidase | 0.0733 | 0.8915 | 0.8915 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0309 | 0.1864 | 0.2091 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.013 | 0.013 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0733 | 0.8915 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.013 | 0.013 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0309 | 0.1864 | 0.2091 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.044 | 0.4039 | 0.4039 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0309 | 0.1864 | 0.2091 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0733 | 0.8915 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4716 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.