Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.0762 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0428 | 0.572 | 0.5523 |
Onchocerca volvulus | 0.009 | 0.0762 | 1 | |
Onchocerca volvulus | 0.009 | 0.0762 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0043 | 0.0969 |
Brugia malayi | ShTK domain containing protein | 0.009 | 0.0762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0704 | 0.9239 |
Echinococcus multilocularis | geminin | 0.0205 | 0.2441 | 0.2094 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0704 | 0.9239 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0704 | 0.9239 |
Loa Loa (eye worm) | tyrosinase 1 | 0.009 | 0.0762 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.072 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.0762 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.009 | 0.0762 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2441 | 0.2094 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2441 | 0.2094 |
Schistosoma mansoni | P2X receptor subunit | 0.072 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.2441 | 0.2094 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0762 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0762 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0043 | 0.0558 |
Schistosoma mansoni | P2X receptor subunit | 0.072 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.072 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.072 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.072 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.072 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0068 | 0.0439 | 0.5765 |
Schistosoma mansoni | eyes absent homolog | 0.0086 | 0.0704 | 0.0277 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.009 | 0.0762 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0439 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.072 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0043 | 0.0969 |
Onchocerca volvulus | 0.009 | 0.0762 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.009 | 0.0762 | 1 |
Onchocerca volvulus | 0.009 | 0.0762 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0068 | 0.0439 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.072 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0428 | 0.572 | 0.5523 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.009 | 0.0762 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0068 | 0.0439 | 0.5765 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.009 | 0.0762 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.