Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | tyrosyl-DNA phosphodiesterase 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | GPCR family 3 C terminal | 0.0145 | 0.0601 | 0.0601 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0145 | 0.0601 | 0.0601 |
Entamoeba histolytica | hypothetical protein | 0.0084 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1016 | 0.9173 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0352 | 0.2633 | 0.2633 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.11 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0601 | 0.0601 |
Leishmania major | extracellular receptor, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0436 | 0.346 | 0.4342 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0145 | 0.0601 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0229 | 0.1427 | 0.1427 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0749 | 0.654 | 0.654 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0084 | 0 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0894 | 0.7968 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0145 | 0.0601 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0601 | 0.0655 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0229 | 0.1427 | 0.1792 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1427 | 0.1427 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0749 | 0.654 | 0.713 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0436 | 0.346 | 0.3772 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0229 | 0.1427 | 0.1427 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.081 | 0.7141 | 0.8962 |
Loa Loa (eye worm) | glutamate receptor | 0.0894 | 0.7968 | 0.7968 |
Loa Loa (eye worm) | hypothetical protein | 0.11 | 1 | 1 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0145 | 0.0601 | 0.0754 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0749 | 0.654 | 0.654 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.