Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1078 | 0.3163 | 0.3163 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.1078 | 0.3163 | 0.3163 |
Giardia lamblia | Kinase, putative | 0.0774 | 0 | 0.5 |
Toxoplasma gondii | bromodomain-containing protein | 0.0774 | 0 | 0.5 |
Entamoeba histolytica | bromodomain-containing protein | 0.0774 | 0 | 0.5 |
Echinococcus granulosus | bromodomain containing 2 | 0.1736 | 1 | 0.5 |
Onchocerca volvulus | 0.0774 | 0 | 0.5 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.1078 | 0.3163 | 0.3163 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.1736 | 1 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.1078 | 0.3163 | 0.3163 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.1736 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.1736 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.1736 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1736 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0774 | 0 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.1078 | 0.3163 | 0.3163 |
Echinococcus multilocularis | bromodomain containing 2 | 0.1736 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.0774 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0963 | 0.1964 | 0.1964 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.