Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.004 | 0.1863 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0221 | 0.1973 | 0.5 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0328 | 0.3245 | 1 |
Onchocerca volvulus | 0.0072 | 0.0215 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0329 | 0.3259 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0054 | 0 | 0.5 |
Brugia malayi | Reduced folate carrier family protein | 0.0054 | 0 | 0.5 |
Echinococcus multilocularis | folate receptor beta | 0.0897 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0328 | 0.3245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0072 | 0.0215 | 0.5 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0054 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0328 | 0.3245 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Brugia malayi | folate-like transporter 3 | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3548 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.