Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0074 | 0.0426 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0469 | 0.0447 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0432 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0022 | 0.0026 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0087 | 0.1223 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0074 | 0.0426 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0022 | 0.0026 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.052 | 0.0598 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0007 | 0.0022 | 0.0026 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0074 | 0.0051 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0432 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0087 | 0.1223 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0022 | 0.0026 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0074 | 0.0085 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.052 | 0.0598 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0395 | 0.3107 |
Entamoeba histolytica | kinesin, putative | 0.0087 | 0.1223 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0074 | 0.0085 |
Plasmodium falciparum | kinesin-5 | 0.0087 | 0.1223 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0074 | 0.0051 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0074 | 0.0051 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0074 | 0.0051 |
Echinococcus multilocularis | kinesin family 1 | 0.0668 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0007 | 0.0022 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0581 | 0.869 | 1 |
Plasmodium vivax | kinesin-5 | 0.0087 | 0.1223 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0087 | 0.1223 | 0.1407 |
Giardia lamblia | Kinesin-5 | 0.0087 | 0.1223 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0469 | 0.372 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0007 | 0.0022 | 0.0026 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0087 | 0.1223 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0469 | 0.0447 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0469 | 0.372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.