Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | prolyl oligopeptidase family protein | 0.0678 | 0.2585 | 0.2344 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0899 | 0.4929 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0899 | 0.4929 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0899 | 0.4929 | 0.3161 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.4236 | 0.2227 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1376 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0479 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1376 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0899 | 0.4929 | 0.4764 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1376 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0899 | 0.4929 | 0.3161 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1376 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0899 | 0.4929 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1376 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0678 | 0.2585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0678 | 0.2585 | 0.2585 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.4236 | 0.2227 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0899 | 0.4929 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0899 | 0.4929 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.4236 | 0.2227 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0899 | 0.4929 | 0.3161 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0329 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 1.2589 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.