Detailed information for compound 144081

Basic information

Technical information
  • TDR Targets ID: 144081
  • Name: 1-[[6-(hydroxymethyl)dithiin-3-yl]methyl]pyri din-2-one
  • MW: 253.341 | Formula: C11H11NO2S2
  • H donors: 1 H acceptors: 2 LogP: 0.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1=CC=C(SS1)Cn1ccccc1=O
  • InChi: 1S/C11H11NO2S2/c13-8-10-5-4-9(15-16-10)7-12-6-2-1-3-11(12)14/h1-6,13H,7-8H2
  • InChiKey: VTWGQHVERVUMKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[[6-(hydroxymethyl)-3-dithiinyl]methyl]-2-pyridinone
  • 1-[[6-(hydroxymethyl)-1,2-dithiin-3-yl]methyl]pyridin-2-one
  • 1-[(6-methyloldithiin-3-yl)methyl]-2-pyridone
  • 1-{[6-(Hydroxymethyl)-1,2-dithiin-3-yl]methyl}hydropyridin-2-one
  • AIDS-032412
  • AIDS032412

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi G-protein coupled receptor 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis sex peptide receptor 0.0132 0.1332 0.1259
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.1332 0.1259
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.1332 0.1259
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0084 0.0084
Echinococcus granulosus g protein coupled receptor 0.0132 0.1332 0.1259
Schistosoma mansoni neuropeptide receptor 0.0132 0.1332 0.1208
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0741 1 1
Schistosoma mansoni opsin-like receptor 0.0132 0.1332 0.1208
Schistosoma mansoni amine GPCR 0.0132 0.1332 0.1208
Echinococcus multilocularis somatostatin receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) melatonin receptor type 1A 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Brugia malayi putative neuropeptide receptor 0.0132 0.1332 0.1332
Echinococcus granulosus allatostatin A receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni amine GPCR 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus dro:myosuppressin receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis neuropeptide receptor A26 0.0132 0.1332 0.1259
Schistosoma mansoni alpha-1 adrenergic receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.5
Brugia malayi follicle stimulating hormone receptor 0.0132 0.1332 0.1332
Schistosoma mansoni opsin-like receptor 0.0132 0.1332 0.1208
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.1332 0.1259
Trypanosoma brucei Peptide deformylase 2 0.0085 0.0668 1
Brugia malayi sulfakinin receptor protein 0.0132 0.1332 0.1332
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0132 0.1332 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus granulosus peptide allatostatin:somatostatin 0.0132 0.1332 0.1259
Echinococcus multilocularis fmrfamide receptor 0.0132 0.1332 0.1259
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0132 0.1332 0.1332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni ceramide glucosyltransferase 0.0741 1 1
Toxoplasma gondii hypothetical protein 0.0223 0.2631 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0668 1
Loa Loa (eye worm) ceramide glucosyltransferase 0.0741 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0132 0.1332 0.1259
Schistosoma mansoni opsin-like receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis g protein coupled receptor 0.0132 0.1332 0.1259
Schistosoma mansoni adenoreceptor 0.0132 0.1332 0.1208
Plasmodium vivax peptide deformylase, putative 0.0223 0.2631 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0132 0.1332 0.1332
Brugia malayi G protein-coupled receptor 0.0132 0.1332 0.1332
Treponema pallidum polypeptide deformylase (def) 0.0223 0.2631 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus granulosus ceramide glucosyltransferase 0.0741 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus alpha 1A adrenergic receptor 0.0132 0.1332 0.1259
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni amine GPCR 0.0132 0.1332 0.1208
Echinococcus granulosus G protein coupled receptor 139 0.0132 0.1332 0.1259
Schistosoma mansoni ceramide glucosyltransferase 0.0741 1 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus sex peptide receptor 0.0132 0.1332 0.1259
Brugia malayi Serotonin receptor 0.0132 0.1332 0.1332
Schistosoma mansoni neuropeptide receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0084 0.0084
Brugia malayi Dopamine receptor protein 1 0.0132 0.1332 0.1332
Echinococcus multilocularis g protein coupled receptor 0.0132 0.1332 0.1259
Brugia malayi AKH receptor 0.0132 0.1332 0.1332
Echinococcus granulosus g-protein coupled receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.1332 0.1259
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis neuropeptides capa receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0132 0.1332 0.1259
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0132 0.1332 0.1259
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus multilocularis neuropeptide receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0132 0.1332 0.1332
Brugia malayi Serotonin receptor 0.0132 0.1332 0.1332
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis neuropeptide s receptor 0.0132 0.1332 0.1259
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0132 0.1332 0.1259
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis G protein coupled receptor 139 0.0132 0.1332 0.1259
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0132 0.1332 0.1259
Giardia lamblia Ceramide glucosyltransferase 0.0336 0.4236 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus neuropeptide receptor 0.0132 0.1332 0.1259
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0132 0.1332 0.1332
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0132 0.1332 0.1259
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.1332 0.1259
Schistosoma mansoni hypothetical protein 0.0132 0.1332 0.1208
Schistosoma mansoni neuropeptide F-like receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni hypothetical protein 0.0132 0.1332 0.1208
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.1332 0.1332
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0132 0.1332 0.1208
Echinococcus granulosus neuropeptide FF receptor 2 0.0132 0.1332 0.1259
Echinococcus granulosus neuropeptides capa receptor 0.0132 0.1332 0.1259
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0223 0.2631 0.5
Schistosoma mansoni biogenic amine receptor 0.0132 0.1332 0.1208
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0132 0.1332 0.1332
Echinococcus multilocularis neuropeptide FF receptor 2 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis serotonin receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Trypanosoma brucei Polypeptide deformylase 1 0.0085 0.0668 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0132 0.1332 0.1259
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis neuropeptide Y receptor 0.0132 0.1332 0.1259
Schistosoma mansoni hypothetical protein 0.0132 0.1332 0.1208
Schistosoma mansoni biogenic amine receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0132 0.1332 0.1259
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0132 0.1332 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis dro:myosuppressin receptor 0.0132 0.1332 0.1259
Echinococcus granulosus somatostatin receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis fmrfamide receptor 0.0132 0.1332 0.1259
Brugia malayi G protein-coupled receptor F59B2.13 0.0132 0.1332 0.1332
Schistosoma mansoni myosin xvIII 0.0132 0.1332 0.1208
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0132 0.1332 0.1332
Echinococcus granulosus tachykinin peptides receptor 99D 0.0132 0.1332 0.1259
Schistosoma mansoni amine GPCR 0.0132 0.1332 0.1208
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni neuropeptide f receptor 76f 0.0132 0.1332 0.1208
Echinococcus multilocularis ceramide glucosyltransferase 0.0741 1 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus serotonin receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.1332 0.1259
Plasmodium falciparum peptide deformylase 0.0223 0.2631 0.5
Schistosoma mansoni neuropeptide receptor 0.0132 0.1332 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus granulosus 7TM GPCR rhodopsin 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0132 0.1332 0.1332
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.1332 0.1259
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0132 0.1332 0.1208
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0132 0.1332 0.1208
Echinococcus multilocularis orexin receptor type 2 0.0132 0.1332 0.1259
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus granulosus neuropeptide Y receptor 0.0132 0.1332 0.1259
Brugia malayi Dopamine receptor 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus fmrfamide receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) neuropeptide F receptor 0.0132 0.1332 0.1332
Schistosoma mansoni biogenic amine receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0132 0.1332 0.1259
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi Dopamine receptor protein 2 0.0132 0.1332 0.1332
Brugia malayi neuropeptide F receptor 0.0132 0.1332 0.1332
Echinococcus multilocularis serotonin receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Leishmania major polypeptide deformylase-like protein, putative 0.0085 0.0668 1
Echinococcus multilocularis neuropeptide receptor 0.0132 0.1332 0.1259
Brugia malayi larval opioid receptor 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi G-protein coupled receptor 0.0132 0.1332 0.1332
Brugia malayi GnHR receptor homolog 0.0132 0.1332 0.1332
Echinococcus granulosus g protein coupled receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) G-protein coupled receptor 0.0132 0.1332 0.1332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0132 0.1332 0.1259
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0223 0.2631 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0223 0.2631 0.5
Brugia malayi ORL1-like opioid receptor 0.0132 0.1332 0.1332
Schistosoma mansoni hypothetical protein 0.0132 0.1332 0.1208
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Mycobacterium ulcerans peptide deformylase 0.0223 0.2631 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0132 0.1332 0.1259
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0132 0.1332 0.1332
Brugia malayi neuropeptide F receptor 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi RE15519p 0.0132 0.1332 0.1332
Brugia malayi Tachykinin-like peptides receptor 99D 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni histamine h1 receptor 0.0132 0.1332 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus multilocularis allatostatin A receptor 0.0132 0.1332 0.1259
Chlamydia trachomatis peptide deformylase 0.0223 0.2631 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.0042 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi Melatonin receptor type 1A 0.0132 0.1332 0.1332
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0132 0.1332 0.1259
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus multilocularis g-protein coupled receptor 0.0132 0.1332 0.1259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0132 0.1332 0.1208
Echinococcus multilocularis rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Brugia malayi putative neuropeptide receptor NPR1 0.0132 0.1332 0.1332
Schistosoma mansoni neuropeptide receptor 0.0132 0.1332 0.1208
Echinococcus granulosus rhodopsin orphan GPCR 0.0132 0.1332 0.1259
Echinococcus granulosus orexin receptor type 2 0.0132 0.1332 0.1259
Echinococcus multilocularis g protein coupled receptor 0.0132 0.1332 0.1259
Echinococcus granulosus 7tm_1 domain containing protein 0.0132 0.1332 0.1259
Echinococcus granulosus g protein coupled receptor 0.0132 0.1332 0.1259
Echinococcus granulosus neuropeptide receptor A26 0.0132 0.1332 0.1259
Echinococcus granulosus neuropeptide receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0132 0.1332 0.1208
Echinococcus granulosus hypothetical protein 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus neuropeptide s receptor 0.0132 0.1332 0.1259
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0132 0.1332 0.1332
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0132 0.1332 0.1208
Schistosoma mansoni growth hormone secretagogue receptor 0.0132 0.1332 0.1208
Echinococcus multilocularis G-protein coupled receptor, putative 0.0132 0.1332 0.1259
Schistosoma mansoni amine GPCR 0.0132 0.1332 0.1208
Loa Loa (eye worm) hypothetical protein 0.0132 0.1332 0.1332
Echinococcus granulosus tm gpcr rhodopsin 0.0132 0.1332 0.1259

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 12.5 ug ml-1 Antifungal activity against cryptococcus neoformans ChEMBL. 7629803
MIC (functional) = 12.5 ug ml-1 Antifungal activity against cryptococcus neoformans ChEMBL. 7629803
MIC (functional) > 100 ug ml-1 Antifungal activity against candida albicans ChEMBL. 7629803
MIC (functional) > 100 ug ml-1 Antifungal activity against aspergillus fumigatus ChEMBL. 7629803
MIC (functional) > 100 ug ml-1 Antifungal activity against candida albicans ChEMBL. 7629803

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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