Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1049 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0558 | 0.2593 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0792 | 0.6124 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0792 | 0.6124 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0792 | 0.6124 | 0.4767 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0393 | 0.0105 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1049 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0792 | 0.6124 | 0.4767 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1049 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1049 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0792 | 0.6124 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1049 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0792 | 0.6124 | 0.4767 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.2593 | 0.2593 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0792 | 0.6124 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0792 | 0.6124 | 0.6124 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0792 | 0.6124 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0558 | 0.2593 | 0.2593 |
Loa Loa (eye worm) | hypothetical protein | 0.0406 | 0.0308 | 0.0308 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.