Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peroxidasin | 0.0147 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0216 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0147 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0147 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0216 | 0.0216 |
Onchocerca volvulus | Dual oxidase homolog | 0.0147 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0147 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0147 | 1 | 1 |
Onchocerca volvulus | 0.0147 | 1 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0147 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0147 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0216 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0147 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Onchocerca volvulus | 0.0147 | 1 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0216 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0147 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0216 | 0.0216 |
Onchocerca volvulus | 0.0147 | 1 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0216 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0216 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1797 | 0.1797 |
Schistosoma mansoni | peroxidasin | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0147 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1797 | 0.1797 |
Brugia malayi | Animal haem peroxidase family protein | 0.0147 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0147 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0147 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0147 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0147 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.