Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1241 | 0.1258 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0955 | 0.9867 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0553 | 0.5387 | 0.546 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.1241 | 0.1258 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0955 | 0.9867 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0955 | 0.9867 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.1241 | 0.1241 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0955 | 0.9867 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0955 | 0.9867 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.093 | 0.9594 | 0.9723 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0069 | 0 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0955 | 0.9867 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0967 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0069 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0955 | 0.9867 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0955 | 0.9867 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0955 | 0.9867 | 0.9867 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.1241 | 0.1258 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1241 | 0.1258 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1241 | 0.1258 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0553 | 0.5387 | 0.5387 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0955 | 0.9867 | 0.9867 |
Onchocerca volvulus | 0.0069 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 3.5481 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.