Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1H subunit | Starlite/ChEMBL | No references |
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0636 | 1 | 1 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0636 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 0.866 | 0.8205 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.0636 | 1 | 0.5 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0262 | 0.3519 | 0.5 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0636 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.3343 | 0.0881 |
Echinococcus granulosus | neuropeptide s receptor | 0.0558 | 0.866 | 0.8205 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.3936 | 0.1877 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.3936 | 0.1877 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 0.866 | 0.8205 |
Onchocerca volvulus | 0.0286 | 0.3944 | 1 | |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0262 | 0.3519 | 0.3519 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0636 | 1 | 1 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.0598 | 0.934 | 0.9109 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0262 | 0.3519 | 0.5 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0636 | 1 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0262 | 0.3519 | 0.1122 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0598 | 0.934 | 0.9109 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0636 | 1 | 1 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0262 | 0.3519 | 0.1244 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0636 | 1 | 0.5 |
Onchocerca volvulus | 0.0262 | 0.3519 | 0.8923 | |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0636 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2534 | 0.2534 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.0636 | 1 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0636 | 1 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0636 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3944 | 0.1818 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0214 | 0.27 | 0.27 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0636 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.3936 | 0.3936 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 0.866 | 0.8205 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0636 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.3936 | 0.1693 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.2534 | 0.2534 |
Mycobacterium tuberculosis | Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase) | 0.0296 | 0.4123 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 6.56 uM | PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] | ChEMBL. | No reference |
Potency (functional) | 0.0828 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.5821 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 32.6294 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.