Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.034 | 0.4074 | 0.4273 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0112 | 0.0071 | 0.0029 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0071 | 0.0074 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2513 | 0.2619 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0112 | 0.0071 | 0.0074 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.0678 | 0.0678 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0678 | 1 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0452 | 0.6037 | 0.6371 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0111 | 0.0043 | 0.0045 |
Brugia malayi | aryl hydrocarbon receptor nuclear translocator protein, putative | 0.0255 | 0.2575 | 0.2717 |
Onchocerca volvulus | 0.0196 | 0.1542 | 0.4893 | |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.023 | 0.2134 | 0.2134 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0678 | 0.0673 |
Mycobacterium ulcerans | putative regulatory protein | 0.0108 | 0 | 0.5 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0198 | 0.1569 | 0.1569 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.0678 | 0.0716 |
Brugia malayi | PAS domain containing protein | 0.0194 | 0.1499 | 0.1582 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.023 | 0.2134 | 0.2134 |
Brugia malayi | hypothetical protein | 0.0648 | 0.9476 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3122 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0452 | 0.6037 | 0.6354 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0043 | 0.0045 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.9476 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.0678 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.0678 | 0.0673 |
Onchocerca volvulus | Protein cycle homolog | 0.0112 | 0.0071 | 0.0139 |
Schistosoma mansoni | aryl hydrocarbon receptor nuclear translocator homolog (darnt) | 0.0255 | 0.2575 | 0.1266 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0195 | 0.1527 | 0.0033 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0678 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2513 | 0.2652 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0198 | 0.1569 | 0.1569 |
Onchocerca volvulus | 0.0286 | 0.3122 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.