Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Zymomonas mobilis (strain ATCC 31821 / ZM4 / CP4) | tRNA-guanine transglycosylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Plasmodium falciparum | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trypanosoma brucei | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | queuine/archaeosine tRNA-ribosyltransferase | 0.0056 | 1 | 0.5 |
Echinococcus multilocularis | queuine tRNA ribosyltransferase | 0.0056 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0045 | 0 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Plasmodium falciparum | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trichomonas vaginalis | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Toxoplasma gondii | queuine trna-ribosyltransferase domain-containing protein | 0.0056 | 1 | 0.5 |
Schistosoma mansoni | queuine tRNA-ribosyltransferase | 0.0056 | 1 | 1 |
Echinococcus granulosus | queuine tRNA ribosyltransferase | 0.0056 | 1 | 1 |
Plasmodium vivax | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Entamoeba histolytica | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Trichomonas vaginalis | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Loa Loa (eye worm) | TRNA Guanine Transglycosylase family member | 0.0056 | 1 | 1 |
Trypanosoma cruzi | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Toxoplasma gondii | queuine tRNA ribosyl transferase | 0.0056 | 1 | 0.5 |
Trypanosoma cruzi | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Plasmodium vivax | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Chlamydia trachomatis | queuine tRNA ribosyltransferase | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0045 | 0 | 0.5 |
Giardia lamblia | tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0 | 0.5 | |
Leishmania major | queuine tRNA-ribosyltransferase, putative | 0.0056 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 8.1 uM | Inhibitory activity against eubacterial tRNA guanine transglycosylase (TGT) from Zymomonas mobilis | ChEMBL. | 12646024 |
Ki (binding) | = 8.1 uM | Inhibitory activity against eubacterial tRNA guanine transglycosylase (TGT) from Zymomonas mobilis | ChEMBL. | 12646024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.