Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.0211 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1104 | 0.2521 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.1104 | 0.2521 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1104 | 0.2521 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0231 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1104 | 0.2521 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1104 | 0.2521 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.2939 | 0.719 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0231 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.0231 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1104 | 0.2521 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1104 | 0.2521 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0231 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1104 | 0.2521 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.