Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0069 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0069 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.5 | 0.5 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.0069 | 0.5 | 0.5 |
Schistosoma mansoni | sphingosine kinase A B | 0.0069 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Compound was evaluated in vitro for the inhibition of CGRP-mediated cAMP production in SK-N-MC cells; not determined | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Displacement of [125I]-hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranes | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | Displacement of [125I]-hCGRP human Calcitonin gene-related peptide type receptor expressed in SK-N-MC neuroblastoma cell membranes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.