Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0136 | 0.0061 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0279 | 0.2096 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0136 | 0.0061 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0136 | 0.0061 | 0.0065 |
Brugia malayi | hypothetical protein | 0.0379 | 0.3524 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0279 | 0.2096 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0279 | 0.2096 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0136 | 0.0061 | 0.5 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0279 | 0.2096 | 0.2227 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0792 | 0.9412 | 0.9409 |
Giardia lamblia | Kinase, CMGC CDK | 0.0136 | 0.0061 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0279 | 0.2096 | 0.2048 |
Giardia lamblia | Kinase, CMGC CDK | 0.0136 | 0.0061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.3524 | 0.3744 |
Entamoeba histolytica | protein kinase, putative | 0.0279 | 0.2096 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0792 | 0.9412 | 0.9409 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.2035 | 0.2162 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0279 | 0.2096 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0279 | 0.2096 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0279 | 0.2096 | 0.5877 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0136 | 0.0061 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0279 | 0.2096 | 0.2048 |
Loa Loa (eye worm) | hypothetical protein | 0.0379 | 0.3524 | 0.3744 |
Plasmodium falciparum | protein kinase 5 | 0.0136 | 0.0061 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0136 | 0.0061 | 0.0065 |
Plasmodium vivax | protein kinase Crk2 | 0.0136 | 0.0061 | 0.5 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0792 | 0.9412 | 0.9409 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.2035 | 0.2162 |
Echinococcus multilocularis | dual specificity | 0.0279 | 0.2096 | 0.2048 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0279 | 0.2096 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0279 | 0.2096 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0792 | 0.9412 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0136 | 0.0061 | 0.0065 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.