Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.048 | 1 | 1 | |
Trypanosoma brucei | hexokinase | 0.048 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.048 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.048 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.2451 | 0.1468 |
Brugia malayi | Hexokinase family protein | 0.048 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.048 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.048 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.048 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.048 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.048 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.048 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0 | 0.5 |
Echinococcus granulosus | hexokinase | 0.048 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.048 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.048 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.048 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.048 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.048 | 1 | 0.5 |
Onchocerca volvulus | 0.048 | 1 | 1 | |
Entamoeba histolytica | hexokinase 1 | 0.048 | 1 | 0.5 |
Onchocerca volvulus | 0.048 | 1 | 1 | |
Echinococcus granulosus | hexokinase | 0.048 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.048 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.048 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.048 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.048 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.048 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.8184 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.