Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0489 | 1 | 0.5 | |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0326 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0489 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0326 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0326 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0326 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0326 | 0 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0489 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0489 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0489 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0489 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0326 | 0 | 0.5 |
Onchocerca volvulus | 0.0489 | 1 | 0.5 | |
Giardia lamblia | Kinase, CDC7 | 0.0489 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0326 | 0 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0326 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0489 | 1 | 1 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0326 | 0 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0489 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0326 | 0 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.0326 | 0 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0326 | 0 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0326 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.6573 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.