Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 1 | 0.0346 | 0.6766 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0346 | 0.6766 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0346 | 0.6766 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0346 | 0.6766 | 1 |
Brugia malayi | Hexokinase family protein | 0.0346 | 0.6766 | 1 |
Brugia malayi | hexokinase | 0.0346 | 0.6766 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Leishmania major | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0993 | 0.1468 |
Onchocerca volvulus | 0.0346 | 0.6766 | 1 | |
Trypanosoma brucei | hexokinase | 0.0346 | 0.6766 | 0.5 |
Onchocerca volvulus | 0.0346 | 0.6766 | 1 | |
Trypanosoma cruzi | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Leishmania major | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0346 | 0.6766 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0346 | 0.6766 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0346 | 0.6766 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0346 | 0.6766 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0346 | 0.6766 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0346 | 0.6766 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 1 | 1 |
Onchocerca volvulus | 0.0346 | 0.6766 | 1 | |
Entamoeba histolytica | hexokinase 2 | 0.0346 | 0.6766 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0063 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.