Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hexokinase, putative | 0.0768 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0768 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0768 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0768 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0768 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 1 | 0.0768 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.0768 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0768 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0768 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0482 | 0.4537 | 0.4537 |
Plasmodium vivax | hexokinase, putative | 0.0768 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.0768 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0768 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0768 | 1 | 0.5 |
Treponema pallidum | hexokinase (hxk) | 0.0768 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0768 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0768 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0768 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0768 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0768 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.0768 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0768 | 1 | 0.5 |
Onchocerca volvulus | 0.0768 | 1 | 1 | |
Onchocerca volvulus | 0.0768 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.5339 | 0.5339 |
Trypanosoma cruzi | hexokinase, putative | 0.0768 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0768 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0768 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0482 | 0.4537 | 0.4537 |
Echinococcus multilocularis | hexokinase | 0.0768 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0768 | 1 | 0.5 |
Onchocerca volvulus | 0.0768 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.