Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | agmatinase, putative | 0.08 | 0 | 0.5 |
Trypanosoma cruzi | arginase, putative | 0.08 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2198 | 1 | 0.5 |
Trypanosoma brucei | agmatinase, putative | 0.08 | 0 | 0.5 |
Trypanosoma cruzi | arginase, putative | 0.08 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2198 | 1 | 0.5 |
Leishmania major | arginase | 0.2198 | 1 | 1 |
Schistosoma mansoni | arginase | 0.2198 | 1 | 0.5 |
Plasmodium vivax | arginase, putative | 0.2198 | 1 | 0.5 |
Echinococcus multilocularis | arginase 2, mitochondrial | 0.2198 | 1 | 0.5 |
Entamoeba histolytica | Arginase, putative | 0.2198 | 1 | 0.5 |
Trichomonas vaginalis | Arginase, putative | 0.2198 | 1 | 0.5 |
Trypanosoma cruzi | agmatinase, putative | 0.08 | 0 | 0.5 |
Echinococcus multilocularis | 0.2198 | 1 | 0.5 | |
Plasmodium falciparum | arginase | 0.2198 | 1 | 0.5 |
Echinococcus granulosus | arginase 2 mitochondrial | 0.2198 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.1582 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 70.7946 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.