Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0086 | 0 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0227 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0227 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0227 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0227 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0227 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0227 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0227 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0227 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0086 | 0 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0086 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.