Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.74 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.74 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.74 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.74 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.74 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.74 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.74 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.74 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.74 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.74 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.74 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.74 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 21.6 uM | Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 mins before menthol challenge measured after 5 mins | ChEMBL. | 20965726 |
IC50 (functional) | = 28.8 uM | Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mins before icilin challenge measured after 5 mins | ChEMBL. | 20965726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.