Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0354 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0354 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0325 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0354 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparasitic activity against Trypanosoma cruzi T2 epimastigotes assessed as growth inhibition at 25 uM after 5 days | ChEMBL. | 20889239 | |
Inhibition (binding) | = 28 % | Inhibition of Trypanosoma cruzi triosephosphate isomerase at 400 uM after 2 hrs | ChEMBL. | 20889239 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.