Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protection of telomeres protein 1 | 0.0568 | 0.0615 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0111 | 0.006 | 0.0392 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.0066 | 1 |
Mycobacterium ulcerans | ion transport protein | 0.0061 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.2266 | 0.2677 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.2266 | 0.2677 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0062 | 0.8398 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.2266 | 0.2677 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.2266 | 0.2677 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0111 | 0.006 | 0.9538 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0111 | 0.006 | 0.0031 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.2266 | 0.2677 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0047 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0116 | 0.0066 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.6031 | 0.7248 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0051 | 0.7058 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0062 | 0.0034 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0111 | 0.006 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0062 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0101 | 0.0047 | 0.5 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0062 | 0.0034 |
Echinococcus multilocularis | protection of telomeres protein 1 | 0.0568 | 0.0615 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Estrogenic potency (functional) | = 8 | Evaluation of oral estrogenic activity by using immature female rats ovariectomized at 21 days of age. | ChEMBL. | 3560158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.