Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0448 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0137 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0448 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0137 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0137 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0137 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0137 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 300 uM | Inhibition of recombinant SHP2 | ChEMBL. | 21193311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.