Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.145 | 0.2695 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.145 | 0.2695 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0285 | 0.0285 | 0.09 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1165 | 0.2104 | 0.7549 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.498 | 1 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0285 | 0.0285 | 0.09 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.498 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.2618 | 0.5111 | 0.4968 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0285 | 0.0285 | 0.0979 |
Brugia malayi | Probable DNA topoisomerase II | 0.145 | 0.2695 | 1 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0285 | 0.0285 | 0.0979 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.2618 | 0.5111 | 0.4968 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.145 | 0.2695 | 1 |
Brugia malayi | DNA topoisomerase III | 0.0285 | 0.0285 | 0.09 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.498 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.145 | 0.2695 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.1034 | 0.3838 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.1034 | 0.3838 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.145 | 0.2695 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.2618 | 0.5111 | 0.4968 |
Leishmania major | DNA topoisomerase ii | 0.1165 | 0.2104 | 0.7549 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.145 | 0.2695 | 0.2481 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0285 | 0.0285 | 0.09 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.145 | 0.2695 | 0.2481 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0285 | 0.0285 | 0.0787 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.498 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.017 | 0.0047 | 0.0173 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.1165 | 0.2104 | 0.7549 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.145 | 0.2695 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2618 | 0.5111 | 0.4968 |
Plasmodium falciparum | DNA gyrase subunit A | 0.498 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.2618 | 0.5111 | 0.4968 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.145 | 0.2695 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.498 | 1 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.145 | 0.2695 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.145 | 0.2695 | 0.2481 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0517 | 0.0764 | 0.0494 |
Giardia lamblia | DNA topoisomerase II | 0.1325 | 0.2436 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0517 | 0.0764 | 0.2836 |
Brugia malayi | GRF zinc finger family protein | 0.0285 | 0.0285 | 0.09 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0933 | 0.1625 | 0.1379 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.2618 | 0.5111 | 0.4968 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0285 | 0.0285 | 0.1057 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.145 | 0.2695 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.145 | 0.2695 | 1 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0285 | 0.0285 | 0.09 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0285 | 0.0285 | 0.0787 |
Schistosoma mansoni | DNA topoisomerase II | 0.145 | 0.2695 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.145 | 0.2695 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.145 | 0.2695 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.145 | 0.2695 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0517 | 0.0764 | 0.2836 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0285 | 0.0285 | 0.1057 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0285 | 0.0285 | 0.09 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.2374 | 0.4607 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.498 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.1165 | 0.2104 | 0.7549 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.2618 | 0.5111 | 0.4968 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.1165 | 0.2104 | 0.7549 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.145 | 0.2695 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 10.86 uM | Cytotoxicity against human MCF7 cells by MTT assay | ChEMBL. | 21115246 |
IC50 (functional) | = 30.43 uM | Cytotoxicity against human HCT15 cells by MTT assay | ChEMBL. | 21115246 |
IC50 (functional) | = 33.47 uM | Cytotoxicity against human K562 cells by MTT assay | ChEMBL. | 21115246 |
IC50 (functional) | = 36.89 uM | Cytotoxicity against human DU145 cells by MTT assay | ChEMBL. | 21115246 |
Inhibition (binding) | = 0 % | Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 at 100 uM by agarose gel electrophoresis | ChEMBL. | 21115246 |
Inhibition (binding) | = 15.18 % | Inhibition of human topoisomerase 2-mediated relaxation of supercoiled pBR322 at 20 uM by agarose gel electrophoresis | ChEMBL. | 21115246 |
Inhibition (binding) | = 22.03 % | Inhibition of human topoisomerase 2-mediated relaxation of supercoiled pBR322 at 100 uM by agarose gel electrophoresis | ChEMBL. | 21115246 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21115246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.