Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 29 % | Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at G2/M phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 15 +/- 4.8%) | ChEMBL. | 21167709 |
Activity (functional) | = 30 % | Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at S phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 36 +/- 4%) | ChEMBL. | 21167709 |
Activity (functional) | = 41 % | Cell cycle arrest in human SH-SY5Y cells assessed as accumulation at G0/G1 phase at 2 times IC50 concentration after 16 hrs by FACS analysis (Rvb = 49 +/- 5.5%) | ChEMBL. | 21167709 |
Activity (functional) | = 51.6 % | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control | ChEMBL. | 21167709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.