Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0214 | 0.0214 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0147 | 0.2217 | 1 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0508 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0147 | 0.2217 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0103 | 0.1266 | 0.5709 |
Echinococcus granulosus | expressed conserved protein | 0.0097 | 0.1131 | 0.5102 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0104 | 0.13 | 0.13 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0103 | 0.1266 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.005 | 0.0134 | 0.0606 |
Schistosoma mansoni | d-amino acid oxidase | 0.0508 | 1 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0103 | 0.1266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1266 | 0.1266 |
Echinococcus multilocularis | expressed conserved protein | 0.0097 | 0.1131 | 0.5102 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0466 | 0.9087 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0508 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0103 | 0.1266 | 0.5709 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 16 mm | Antifungal activity against Candida albicans at 100 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 17 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 100 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 17 mm | Antifungal activity against Candida albicans at 200 ug/ml after 48 hrs by agar diffusion method | ChEMBL. | 20965619 |
IZ (functional) | = 19 mm | Antibacterial activity against Escherichia coli ATCC 25922 at 200 ug/ml after 24 hrs by disc-diffusion method | ChEMBL. | 20965619 |
MBC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs | ChEMBL. | 20965619 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth dilution technique | ChEMBL. | 20965619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.