Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
solubility (functional) | = 0.12 % | Antitubercular activity against Mycobacterium tuberculosis infected in BALB/c mouse assessed as reduction in lung microbial load at 100 mg/kg, po qd for 5 days per week for 3 weeks administered 11 days post infection relative to OPC-67683 | ChEMBL. | 21069962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.