Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.2141 | 0.3441 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3152 | 1 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.2575 | 0.6253 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3152 | 1 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3152 | 1 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.2575 | 0.6253 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.2575 | 0.6253 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.2575 | 0.6253 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.2575 | 0.6253 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.2141 | 0.3441 | 0.3441 |
Loa Loa (eye worm) | hypothetical protein | 0.3152 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.45 | Inhibition of horse serum BChE preincubated for 5 mins by Ellman's method | ChEMBL. | 20926161 |
Inhibition (binding) | Inhibition of electric eel AChE at 100 uM preincubated for 5 mins by Ellman's method | ChEMBL. | 20926161 | |
Inhibition (binding) | = 77.73 % | Inhibition of horse serum BChE at 100 uM preincubated for 5 mins by Ellman's method | ChEMBL. | 20926161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.