Detailed information for compound 146562

Basic information

Technical information
  • TDR Targets ID: 146562
  • Name: 5-[[4-[2-hydroxy-2-(5-methyl-2-phenyl-1,3-oxa zol-4-yl)ethoxy]phenyl]methyl]-1,3-thiazolidi ne-2,4-dione
  • MW: 424.47 | Formula: C22H20N2O5S
  • H donors: 2 H acceptors: 4 LogP: 3.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC(c1nc(oc1C)c1ccccc1)O
  • InChi: 1S/C22H20N2O5S/c1-13-19(23-21(29-13)15-5-3-2-4-6-15)17(25)12-28-16-9-7-14(8-10-16)11-18-20(26)24-22(27)30-18/h2-10,17-18,25H,11-12H2,1H3,(H,24,26,27)
  • InChiKey: YVQKIDLSVHRBGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[4-[2-hydroxy-2-(5-methyl-2-phenyl-oxazol-4-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • 5-[[4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
  • 5-[4-[2-hydroxy-2-(5-methyl-2-phenyl-oxazol-4-yl)ethoxy]benzyl]thiazolidine-2,4-quinone
  • AD 5075
  • 103788-05-2
  • 2,4-Thiazolidinedione, 5-((4-(2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy)phenyl)methyl)-
  • 5-(4-(2-(5-Methyl-2-phenyl-4-oxazolyl)-2-hydroxyethoxy)benzyl)-2,4-thiazolidinedione
  • AD-5075

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0029 0.3091 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0068 1 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.006 0.8512 0.8512
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.3091 0.3996
Schistosoma mansoni jun-related protein 0.0055 0.7736 1
Entamoeba histolytica hypothetical protein 0.0029 0.3091 0.5
Echinococcus multilocularis jun protein 0.0068 1 1
Schistosoma mansoni hypothetical protein 0.0029 0.3091 0.3996
Echinococcus granulosus jun protein 0.0068 1 1
Schistosoma mansoni hypothetical protein 0.0055 0.7736 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.3091 0.3091
Onchocerca volvulus 0.0053 0.7404 0.5
Entamoeba histolytica hypothetical protein 0.0029 0.3091 0.5
Loa Loa (eye worm) hypothetical protein 0.0066 0.9669 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.3091 0.3091
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0068 1 1
Brugia malayi hypothetical protein 0.0053 0.7404 0.6243
Echinococcus multilocularis nuclear factor of activated T cells 5 0.006 0.8512 0.8512
Entamoeba histolytica hypothetical protein 0.0029 0.3091 0.5

Activities

Activity type Activity value Assay description Source Reference
ED25 (functional) = 0.05 mg kg-1 day-1 Effective dose to reduce 25% of glucose levels in blood ChEMBL. 1635060
ED25 (functional) = 0.05 mg kg-1 day-1 Effective dose to reduce 25% of glucose levels in blood ChEMBL. 1635060
ED25 (functional) = 0.1 mg kg-1 day-1 Effective dose to reduce 25% of triglyceride levels in plasma ChEMBL. 1635060
ED25 (functional) = 0.1 mg kg-1 day-1 Effective dose to reduce 25% of triglyceride levels in plasma ChEMBL. 1635060
Reduction (functional) = 54 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.001% in diet ChEMBL. 1635060
Reduction (functional) = 54 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.001% in diet ChEMBL. 1635060
Reduction (functional) = 58 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 58 % Maximum reduction in blood glucose levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 62 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.001% in diet ChEMBL. 1635060
Reduction (functional) = 62 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.001% in diet ChEMBL. 1635060
Reduction (functional) = 81 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060
Reduction (functional) = 81 % Maximum reduction in plasma triglyceride levels in KKA mice at a dosage of 0.005% in diet ChEMBL. 1635060

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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