Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.5 | 0.5 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Echinococcus multilocularis | enteropeptidase | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Echinococcus granulosus | Mastin | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Echinococcus granulosus | enteropeptidase | 0.0243 | 0.5 | 0.5 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0243 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Echinococcus multilocularis | Mastin | 0.0243 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0243 | 0.5 | 0.5 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0243 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 6.25 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 30 days by agar microdilution method | ChEMBL. | 20970222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.