Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Xanthine dehydrogenase | Starlite/ChEMBL | References |
Rattus norvegicus | Xanthine dehydrogenase/oxidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | aldehyde oxidase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | Get druggable targets OG5_127252 | All targets in OG5_127252 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0418 | 0.2799 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1176 | 1 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0197 | 0.0696 | 0.4783 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1176 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0277 | 0.1456 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1176 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1176 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0141 | 0.0164 | 0.1125 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0141 | 0.0164 | 0.1125 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1176 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0701 | 0.5486 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1176 | 1 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0197 | 0.0696 | 0.4783 |
Leishmania major | carbonic anhydrase-like protein | 0.1176 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1176 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1176 | 1 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0418 | 0.2799 | 0.5 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0197 | 0.0696 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0418 | 0.2799 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1176 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1176 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0701 | 0.5486 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.