Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0093 | 0 | 0.5 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2472 | 0.4439 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.5452 | 1 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5452 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0093 | 0 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5452 | 1 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.5452 | 1 | 0.5 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.5452 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0093 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0093 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0093 | 0 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.5452 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 12.5 uM | Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 12.5 uM | Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 12.5 uM | Evaluated for the inhibition of cell proliferation induced by VEGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 12.5 uM | Evaluated for the inhibition of cell proliferation induced by FGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 | ChEMBL. | 10893303 |
IC50 (binding) | > 20 uM | Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase | ChEMBL. | 10893303 |
IC50 (functional) | > 50 uM | Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 50 uM | Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 50 uM | Evaluated for the inhibition of cell proliferation induced by PDGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (functional) | > 50 uM | Evaluated for the inhibition of cell proliferation induced by EGF in HUVEC or NIH3T3 cells | ChEMBL. | 10893303 |
IC50 (binding) | = 70.6 uM | Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta | ChEMBL. | 10893303 |
IC50 (binding) | = 70.6 uM | Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta | ChEMBL. | 10893303 |
IC50 (binding) | > 100 uM | Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor | ChEMBL. | 10893303 |
IC50 (binding) | > 100 uM | Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor | ChEMBL. | 10893303 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10893303 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.