Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.4961 | 0.991 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.5004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.0081 | 0.0081 |
Onchocerca volvulus | 0.0354 | 0.0093 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.5004 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.4961 | 0.991 | 0.5 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0474 | 0.0348 | 0.0259 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.4961 | 0.991 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0474 | 0.0348 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.4961 | 0.991 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.4961 | 0.991 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.4961 | 0.991 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.4961 | 0.991 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.4961 | 0.991 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.4961 | 0.991 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.4961 | 0.991 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0474 | 0.0348 | 0.0348 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.4961 | 0.991 | 0.991 |
Toxoplasma gondii | hypothetical protein | 0.5004 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.4961 | 0.991 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0474 | 0.0348 | 0.0271 |
Loa Loa (eye worm) | hypothetical protein | 0.5004 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.