Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.4603 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0243 | 0.0026 | 0.0026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0243 | 0.0026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4603 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.3913 | 0.8422 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.3913 | 0.8422 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.3913 | 0.8422 | 0.5 |
Echinococcus granulosus | discoidin domain receptor | 0.026 | 0.0065 | 0.0047 |
Onchocerca volvulus | 0.0264 | 0.0075 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.3913 | 0.8422 | 0.8422 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.3913 | 0.8422 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0264 | 0.0075 | 0.0058 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.3913 | 0.8422 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.3913 | 0.8422 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.3913 | 0.8422 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.3913 | 0.8422 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.3913 | 0.8422 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.3913 | 0.8422 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.4603 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.4603 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.3913 | 0.8422 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.