Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0014 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0014 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0014 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0014 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0014 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0014 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0014 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0014 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.