Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peroxidasin | 0.0163 | 0.1927 | 0.2433 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1403 | 0.1403 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0163 | 0.1926 | 0.1926 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.1403 | 0.1403 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0163 | 0.1926 | 0.1926 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0358 | 0.5265 | 0.5265 |
Echinococcus granulosus | peroxidasin | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0074 | 0.0074 |
Schistosoma mansoni | amine GPCR | 0.0343 | 0.5013 | 0.4757 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1403 | 0.1403 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0084 | 0.0583 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0084 | 0.0583 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0445 | 0.6756 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0358 | 0.5265 | 0.5265 |
Schistosoma mansoni | serine-rich repeat protein | 0.0084 | 0.058 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | peroxidasin | 0.0163 | 0.1927 | 0.1927 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0308 | 0.4419 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0132 | 0.1403 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.058 | 0.0096 |
Brugia malayi | hypothetical protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0634 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.1927 | 0.1513 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0551 | 0.8583 | 0.851 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0084 | 0.0583 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0163 | 0.1927 | 0.2433 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.6756 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.4117 | 0.4117 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.1927 | 0.1513 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.3607 | 0.3607 |
Giardia lamblia | Telomerase catalytic subunit | 0.0084 | 0.0583 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0634 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.6756 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0132 | 0.1403 | 0.1403 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Echinococcus multilocularis | serotonin receptor | 0.0132 | 0.1403 | 0.1403 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.6756 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3033 | 0.3033 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0156 | 0.1813 | 0.1393 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.6756 | 0.6756 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Brugia malayi | Telomerase reverse transcriptase | 0.0224 | 0.2977 | 0.4079 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.1927 | 0.2433 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1927 | 0.1927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.