Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | clathrin coat assembly protein AP17, putative | 0.0032 | 0.5 | 0.5 |
Trypanosoma cruzi | clathrin coat assembly protein AP17, putative | 0.0032 | 0.5 | 0.5 |
Plasmodium falciparum | AP-2 complex subunit sigma, putative | 0.0032 | 0.5 | 0.5 |
Loa Loa (eye worm) | clathrin adaptor complex small chain | 0.0032 | 0.5 | 0.5 |
Plasmodium vivax | AP-2 complex subunit sigma, putative | 0.0032 | 0.5 | 0.5 |
Giardia lamblia | Sigma adaptin | 0.0032 | 0.5 | 0.5 |
Entamoeba histolytica | clathrin adaptor complex small chain, putative | 0.0032 | 0.5 | 0.5 |
Echinococcus granulosus | clathrin coat assembly protein ap17 | 0.0032 | 0.5 | 0.5 |
Echinococcus multilocularis | clathrin coat assembly protein ap17 | 0.0032 | 0.5 | 0.5 |
Trichomonas vaginalis | clathrin coat assembly protein ap19, putative | 0.0032 | 0.5 | 0.5 |
Trichomonas vaginalis | clathrin coat assembly protein ap19, putative | 0.0032 | 0.5 | 0.5 |
Toxoplasma gondii | AP-2 complex subunit sigma-1, putative | 0.0032 | 0.5 | 0.5 |
Trichomonas vaginalis | clathrin coat assembly protein ap17, putative | 0.0032 | 0.5 | 0.5 |
Schistosoma mansoni | clathrin coat assembly protein AP17 | 0.0032 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.