Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.022 | 0.0098 |
Brugia malayi | RNA binding protein | 0.0454 | 0.369 | 0.369 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.022 | 0.0098 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0119 | 0.0859 | 0.1045 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0119 | 0.0859 | 0.1045 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0081 | 0.0081 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0119 | 0.0859 | 0.0859 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.038 | 0.3063 | 0.4314 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0036 | 0.0154 | 0.5 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0119 | 0.0859 | 0.1045 |
Echinococcus granulosus | geminin | 0.0191 | 0.1471 | 0.1954 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0845 | 0.077 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Loa Loa (eye worm) | hypothetical protein | 0.0188 | 0.1443 | 0.1373 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0119 | 0.0859 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.3063 | 0.3007 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0293 | 0.2333 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0454 | 0.369 | 0.5245 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0036 | 0.0154 | 0.0154 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.022 | 1 |
Schistosoma mansoni | apoptosis regulator bax | 0.0056 | 0.033 | 0.0261 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0041 | 0.0203 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.12 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0454 | 0.369 | 0.5245 |
Schistosoma mansoni | hypothetical protein | 0.038 | 0.3063 | 0.4314 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0454 | 0.369 | 0.3639 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0794 | 0.0719 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0056 | 0.033 | 0.0261 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0036 | 0.0154 | 0.0154 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0293 | 0.2333 | 0.3231 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.033 | 0.0261 |
Loa Loa (eye worm) | RNA binding protein | 0.0454 | 0.369 | 0.3639 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0161 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.033 | 0.0251 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0036 | 0.0154 | 0.0154 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0265 | 0.2092 | 0.2092 |
Schistosoma mansoni | tar DNA-binding protein | 0.0454 | 0.369 | 0.5245 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1471 | 0.1954 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 0.2333 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.2936 | 0.2879 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.6897 | 1 |
Brugia malayi | TAR-binding protein | 0.0454 | 0.369 | 0.369 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0041 | 0.0203 | 0.0542 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0056 | 0.033 | 0.0261 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.038 | 0.3063 | 0.4314 |
Toxoplasma gondii | hypothetical protein | 0.0036 | 0.0161 | 0.0355 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 0.2333 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.022 | 1 |
Loa Loa (eye worm) | calcium channel | 0.0119 | 0.0859 | 0.0784 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0293 | 0.2333 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0119 | 0.0859 | 0.1045 |
Schistosoma mansoni | tar DNA-binding protein | 0.0454 | 0.369 | 0.5245 |
Schistosoma mansoni | tar DNA-binding protein | 0.0454 | 0.369 | 0.5245 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.12 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.6897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2092 | 0.2027 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.038 | 0.3063 | 0.3007 |
Schistosoma mansoni | tar DNA-binding protein | 0.0454 | 0.369 | 0.5245 |
Loa Loa (eye worm) | hypothetical protein | 0.0821 | 0.6789 | 0.6763 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0119 | 0.0859 | 0.1045 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0859 | 0.0784 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0056 | 0.033 | 0.0261 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0036 | 0.0154 | 0.0154 |
Brugia malayi | Isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.2333 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0188 | 0.1443 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 0.2333 | 1 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0119 | 0.0859 | 0.1045 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1471 | 0.1954 |
Schistosoma mansoni | voltage-gated cation channel | 0.0119 | 0.0859 | 0.1045 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0041 | 0.0203 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0161 | 0.0081 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0293 | 0.2333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1023 | 0.095 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0036 | 0.0154 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.038 | 0.3063 | 0.4314 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.1023 | 0.095 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0293 | 0.2333 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0293 | 0.2333 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0188 | 0.1443 | 0.1443 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0821 | 0.6789 | 0.6789 |
Schistosoma mansoni | hypothetical protein | 0.0821 | 0.6789 | 0.984 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0036 | 0.0154 | 0.0074 |
Brugia malayi | Latrophilin receptor protein 2 | 0.038 | 0.3063 | 0.3063 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.038 | 0.3063 | 0.4314 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0041 | 0.0203 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1471 | 0.1954 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.022 | 0.0098 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0036 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0056 | 0.033 | 0.0251 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.12 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.038 | 0.3063 | 0.4314 |
Loa Loa (eye worm) | TAR-binding protein | 0.0454 | 0.369 | 0.3639 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0056 | 0.033 | 0.033 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0119 | 0.0859 | 0.1045 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.038 | 0.3063 | 0.3063 |
Schistosoma mansoni | hypothetical protein | 0.0365 | 0.2936 | 0.4126 |
Brugia malayi | isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.2333 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0036 | 0.0154 | 0.5 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0041 | 0.0203 | 0.0542 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0203 | 0.0123 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0293 | 0.2333 | 1 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0036 | 0.0154 | 0.0324 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0293 | 0.2333 | 1 |
Brugia malayi | hypothetical protein | 0.0138 | 0.1023 | 0.1023 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0235 | 0.1842 | 0.2504 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0056 | 0.033 | 0.0261 |
Schistosoma mansoni | hypothetical protein | 0.038 | 0.3063 | 0.4314 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0056 | 0.033 | 0.0261 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0901 | 0.0827 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.038 | 0.3063 | 0.4314 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0365 | 0.2936 | 0.4126 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0119 | 0.0859 | 0.1045 |
Echinococcus granulosus | tar DNA binding protein | 0.0454 | 0.369 | 0.5245 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0454 | 0.369 | 0.369 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.033 | 0.0261 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.033 | 0.0261 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0036 | 0.0154 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.022 | 0.022 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0154 | 0.0074 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0365 | 0.2936 | 0.4126 |
Echinococcus granulosus | GPCR family 2 | 0.038 | 0.3063 | 0.4314 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.022 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.022 | 0.0098 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.227 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0119 | 0.0859 | 0.1045 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0365 | 0.2936 | 0.4126 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.6897 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.038 | 0.3063 | 0.4314 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0293 | 0.2333 | 0.3231 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0119 | 0.0859 | 0.1045 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0119 | 0.0859 | 0.1045 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.