Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0715 | 0.8232 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0104 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0846 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0715 | 0.8232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.082 | 0.0996 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0715 | 0.8232 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0814 | 0.957 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0715 | 0.8232 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0715 | 0.8232 | 0.8603 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0104 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.082 | 0.0996 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0414 | 0.4173 | 0.4173 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0715 | 0.8232 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0165 | 0.082 | 0.0996 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0715 | 0.8232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.082 | 0.0996 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0104 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0414 | 0.4173 | 0.436 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0104 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0104 | 0 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0715 | 0.8232 | 0.8232 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0715 | 0.8232 | 0.8232 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0715 | 0.8232 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0207 | 0.139 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.