Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Caenorhabditis elegans | Protein MEX-5 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0206 | 0.6172 | 0.617 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0055 | 0.0007 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0055 | 0.0007 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0055 | 0.0007 | 1 |
Toxoplasma gondii | PAN domain-containing protein | 0.0299 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0055 | 0.0007 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0055 | 0.0007 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0007 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0007 | 1 |
Onchocerca volvulus | 0.0055 | 0.0007 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0007 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0055 | 0.0007 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0055 | 0.0007 | 1 |
Brugia malayi | Kringle domain containing protein | 0.0055 | 0.0007 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 10.948 um | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of Mex-5 Binding to TCR-2. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] | ChEMBL. | No reference |
EC50 (binding) | > 300 um | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Identify Inhibitors of POS-1 Binding to mex-3-RNA. (Class of assay: confirmatory) [Related pubchem assays: 1833 (Project Summary), 1832 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.