Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0185 | 0.2776 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5546 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0115 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.308 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.0185 | 0.2776 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0254 | 0.5546 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0185 | 0.2776 | 0.5004 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0185 | 0.2776 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0254 | 0.5546 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0254 | 0.5546 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0254 | 0.5546 | 1 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0185 | 0.2776 | 0.5004 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0254 | 0.5546 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0185 | 0.2776 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0185 | 0.2776 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.308 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0115 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.