Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | arginine N-methyltransferase-like protein | 0.0033 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0087 | 1 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0052 | 0.3477 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0054 | 0.3931 | 1 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit alpha | 0.0054 | 0.3931 | 0.3931 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.0087 | 1 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0087 | 1 | 1 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0033 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.0087 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.0087 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0054 | 0.3931 | 1 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0033 | 0 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.0087 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0054 | 0.3931 | 1 |
Schistosoma mansoni | beta-hexosaminidase B | 0.0087 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0054 | 0.3931 | 1 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0052 | 0.3477 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit alpha | 0.0054 | 0.3931 | 0.3931 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.0087 | 1 | 1 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0052 | 0.3477 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.