Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | rheb, putative | 0.0055 | 1 | 0.5 |
Entamoeba histolytica | ras-1, putative | 0.0055 | 1 | 0.5 |
Trichomonas vaginalis | rap1 and, putative | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0013 | 0 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0055 | 1 | 0.5 |
Echinococcus multilocularis | ras gtpase | 0.0055 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | ral, putative | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | ras gtpase | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0055 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | dexras1, putative | 0.0055 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0013 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0013 | 0 | 0.5 |
Entamoeba histolytica | Ras family GTPase | 0.0055 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0013 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 1 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Compound was tested for ability to extend the life span of Plasmodium berghei infected mice; no activity | ChEMBL. | 7420359 | |
Activity (binding) | Compound was tested for the inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase (from H.Ep.2 cells); no activity | ChEMBL. | 7420359 | |
Activity (functional) | NA 0 | Compound was tested for ability to extend the life span of Plasmodium berghei infected mice; no activity | ChEMBL. | 7420359 |
Activity (binding) | NA 0 | Compound was tested for the inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase (from H.Ep.2 cells); no activity | ChEMBL. | 7420359 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.