Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.9905 | 0.9905 |
Plasmodium vivax | pyruvate kinase, putative | 0.0144 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0144 | 1 | 0.5 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.05 | 0.05 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.05 | 0.05 |
Leishmania major | pyruvate kinase | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0144 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0074 | 0.4457 | 0.4165 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0089 | 0.5663 | 0.5663 |
Brugia malayi | pyruvate kinase | 0.003 | 0.1011 | 0.0538 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0144 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.9905 | 0.9905 |
Leishmania major | pyruvate kinase | 0.0144 | 1 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Chlamydia trachomatis | pyruvate kinase | 0.0144 | 1 | 0.5 |
Entamoeba histolytica | pyruvate kinase, putative | 0.01 | 0.6554 | 0.5 |
Echinococcus granulosus | RUN | 0.0024 | 0.05 | 0.05 |
Schistosoma mansoni | loxhd1 | 0.0024 | 0.05 | 0.05 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0144 | 1 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0089 | 0.5663 | 0.5663 |
Echinococcus multilocularis | pyruvate kinase | 0.0113 | 0.7601 | 0.7601 |
Schistosoma mansoni | rab6-interacting | 0.0024 | 0.05 | 0.05 |
Schistosoma mansoni | pyruvate kinase | 0.0144 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.6554 | 0.6554 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.01 | 0.6554 | 0.6554 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0074 | 0.4457 | 0.4165 |
Plasmodium falciparum | pyruvate kinase | 0.0144 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0024 | 0.05 | 0.05 |
Schistosoma mansoni | polycystin 1-related | 0.0024 | 0.05 | 0.05 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.05 | 0.05 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0024 | 0.05 | 0.05 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.05 | 0.05 |
Echinococcus multilocularis | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0144 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0144 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.05 | 0.05 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0144 | 1 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0144 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0144 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0144 | 1 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.6507 | 0.6507 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0024 | 0.05 | 0.05 |
Echinococcus granulosus | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0144 | 1 | 0.5 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0043 | 0.2058 | 0.164 |
Giardia lamblia | Pyruvate kinase | 0.0144 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0144 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0144 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0144 | 1 | 1 |
Echinococcus multilocularis | RUN | 0.0024 | 0.05 | 0.05 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0144 | 1 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.003 | 0.1011 | 0.1011 |
Echinococcus multilocularis | pyruvate kinase | 0.0144 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.9905 | 0.9905 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0024 | 0.05 | 0.05 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0144 | 1 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0074 | 0.4457 | 0.4457 |
Brugia malayi | pyruvate kinase, muscle isozyme | 0.003 | 0.1011 | 0.0538 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.05 | 0.05 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0024 | 0.05 | 0.05 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.