Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.6539 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.012 | 0.3274 | 0.5006 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0707 | 0.1081 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.6539 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.012 | 0.3274 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.5369 | 1 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.012 | 0.3274 | 0.5006 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.012 | 0.3274 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.6539 | 1 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.012 | 0.3274 | 1 |
Onchocerca volvulus | 0.0114 | 0.2996 | 0.5 | |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.5369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0707 | 0.1081 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.012 | 0.3274 | 0.5006 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.012 | 0.3274 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0707 | 0.1081 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.012 | 0.3274 | 0.5006 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.012 | 0.3274 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0707 | 0.1081 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.6539 | 1 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.012 | 0.3274 | 1 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.012 | 0.3274 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.6539 | 1 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.012 | 0.3274 | 1 |
Entamoeba histolytica | ubiquitin-conjugating enzyme family protein | 0.012 | 0.3274 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.012 | 0.3274 | 0.5006 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.012 | 0.3274 | 0.5006 |
Plasmodium falciparum | ubiquitin-conjugating enzyme E2 N, putative | 0.012 | 0.3274 | 0.5 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.012 | 0.3274 | 0.6097 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 26.2 uM | PubChem BioAssay. SAR analysis of small molecule inhibitors of SKN-1 in a fluorescence ratio assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | 64 uM | PubChem BioAssay. SAR analysis of small molecule inhibitors of SKN-1 via a heat-shock counterscreen assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.